This page displays methods developed in the Corey group since 1950.

Method Year Affected Functional Group Newly Formed Functional Group Reagents and/or Catalysts Method Keyword(s) Relevant Publication Link(s) Image
Protection-Deprotection of Indoles2003indoleNA4-methyl-1,2,4-triazoline-3,5-dione (MTAD)indole protection 990

Synthesis and intramolecular cyclopropanation with diazoesters1984NANAglyoxylic acid chloride p-toluenesulfonylhydrazone, bis(N-tert-butylsalicylaldiminato)copper (II)cyclopropanation, diazoester 569

t-Butoxymethyllithium as a hydroxymethyl anion equivalent1983NANAtert-butyl methyl ether, potassium tert-butoxide-sec-butyllithium, lithium bromidemetallation 521

Zinc or Magnesium Triflate-Catalyzed Thioketalization1983ketonethioketalmagnesium triflate or zinc triflateprotecting group 503

Formation of α,β-Epoxy Systems From β-Peroxy Carbon Free Radicals1983peroxymercurialepoxideMercuric trifluoroacetate, borohydrideRadical cyclization, reduction 522

Simple Synthesis of Alkoxy- and Aryloxymethyllithium Reagents1983NANATin (II) chloride lithium bromide complexmetallation 520

Radical cyclization of ketones forming cyclopentanols1983ketonealcoholzinc (powder), trimethylchlorosilanereduction, radical cyclization 517

Flexible annulation forming cyclohexenones1978NANAα-lithio N,N-dimethylhydrazone cuprateannulation, cyclization, conjugate addition 396

Oxidative cationic cyclizations using PCC1978alcoholenonepyridinium chlorochromateoxidation 389

Annulation processes based on benzothiazoles1978NANAbenzothiazoleannulation, cyclization, aldehyde protection 379

Benzothiazoles as carbonyl equivalents1978aldehydealdehydebenzothiazolealdehyde equivalent, aldehyde protection, alkylation, conjugate addition 377 378

A Translactonization Route to Macrocyclic Lactones1977NANAp-toluenesulfonic acidInternal translactonization, ring expansion 373

A Novel α-Alkylation of α-β-Epoxy Ketones1975α-β-unsaturated ketoneβ-hydroxy ketonedimethylcopper lithium, di-n-butylcopper lithium, hydroxylamine hydrochlorideα-alkylation, conjugate additions, vinyl nitroso anions, β-hydroxy ketones 452 374 332

A Method for Catalytic Dehalogenation via Trialkyltin Hydrides1975Alkyl iodide, alky lbromidealkanetrimethyltin chloridedehalogenation 364 456

Alkylation of Thallous Cyclopentadienide1971NANAThallous cyclopentadienidealkylation 219

Synthesis of 1,3-Dithiane1965DithiolDithianeAcetic acid, boron trifluoride-diethyl etherate1,3-Dithiane 121 122 217

Dimethylsulfonium methylide - a reagent for selective oxirane synthesis1962Aldehydes and ketonesEpoxide (oxirane)Dimethylsulfonium methylideEpoxide formation 80 75 76 89 90